Life should be lived. You need to do what you love and love what you do and I don't believe you can do this without some flexibility. I have flexed in my role in the last 20+ years, either due to where I live as I am such a country girl, meaning I normally live miles away from any 'business hub' or due to family needs and the distance impacting that too. I have been fortunate (or rather its been very much by design) to have worked for organisations that can see the value of flexing. I once resigned on the spot from an organisation who 'told me off' one day for working from home the day after winning a large deal.
I also have an amazing husband who 'flexed' after the birth of our first son (who is now a strapping 16 year old) at the time I was working for a large Global IT communications company and was the first female sales person to secure a pat time role and I am proud to say that I paved the way for other women that you can work part time and be successful in your role.
I am also proud to have been a founding member of the Mercer 'All roles can flex' employee resource group whilst working there.